The pharmacology of antiarrhythmic drugs is particularly important because patients with cardiac arrhythmias frequently have multiorgan disease, which may influence the metabolism and elimination of antiarrhythmic drugs. They are the most common cause of death in patients who have had a myocardial infarction, and over 80% of patients with an acute myocardial infarction have arrhythmias. Sodiumchannel blockers comprise the class i antiarrhythmic compounds according to the vaughanwilliams classification scheme. These drugs are classified based antiarrhythmic drugs knowledge for medical students and physicians. The pharmacodynamics of an antiarrhythmic drug determines not only the actions in specific arrhythmias but also the chronotropic, inotropic, and toxic effects. Reentry is the most common cardiac conduction abnormality leading to arrhythmias. Set 1 powerpoint links collected from the website of.
The adobe flash plugin is needed to view this content. The efficacy of many antiarrhythmic agents remains pharm 5th db 209 32111 2. Many attempts have been made to classify antiarrhythmic agents. To better understand this condition, there are two concepts vital to be mastered.
They also reduce conduction and excitability and increase the refractory period to a greater extent in depolarized tissue than in normally polarized tissue. This will not only help clinicians to select proper antiarrhythmic drugs, but will also help in the development of new antiarrhythmic drugs. In todays medical quiz, well be looking at antiarrhythmics, which are pharmaceuticals that help to ease abnormal rhythms of the heart, which can come about as a result of a number of different heart conditions. Normal electrical cardiac function normal sinus rhythm, nsr is dependent on generation of an impulse in the normal sinoatrial sa node pacemaker and its conduction through the atrial muscle, through the atrioventricular av node, through the purkinje conduction system, to the ventricular muscle figure 141 where it is finally extinguished after activating all the myocytes. Try it if you have insomnia in the lecture confusion as always in the exam hall panic. In contrast, many of the antiarrhythmic agents are now known to have dangerous proarrhythmic actionsthat is, to cause arrhythmias. Download and install current free versions of quicktime, if needed, to support lecture series audio. Antiarrhythmic pharmacological agents are used in both the emergent and long term management of cardiac arrhythmias. A free powerpoint ppt presentation displayed as a flash slide show on id. Better understand the complexities of pharmacology and physiology relevant to your practice with the brandnew medical reference book, pharmacology and physiology for anesthesia. For antiarrhythmic drugs, the primary mechanism of action is based on their effects on certain ion channels and receptors located on the myocardial cell membrane. Antiarrhythmic agents antiarrhythmic drugs are used to prevent or treat irregularities of cardiac rhythm. A contemporary view is that all drugs exert their desirable and undesirable effects by interacting with specific molecular targets.
The davis basic science cardiovascular laboratory focuses on various aspects of cardiac regeneration and preservation using molecularbased and biomaterialsbased approaches to restoring function after cardiac injury. Start studying antiarrhythmic drugs pharmacology summer ppt 3 dr. Clinical pharmacology of antiarrhythmic drugs ischemic heart disease there are 35 risk factors for development of ihd 3. Ppt antiarrhythmic drugs powerpoint presentation free to. The long and growing list of non antiarrhythmic drugs associated with prolongation of the qt interval of the electrocardiogram has generated concern not only for regulatory interventions leading. The south university school of pharmacys educational outcomes related to content on the pharmacotherapy of arrhythmias are listed in table 1, along with the coursespecific learning objectives for content on the pharmacology of antiarrhythmic drugs. Hugh hemmings and talmage egan provide the clinical insights you need to effectively administer anesthesia, ensuring patient safety and the most optimal outcomes. Antiarrhythmic drugs basic concepts in pharmacology. Medical pharmacology cardiovascular pharmacology lecture. Pdf to provide doctor of pharmacy pharmd students with highly integrated, comprehensive and.
The antiarrhythmic drug quinidine gluconate quinaglute, quinalan can cause this arrhythmia. Cardiac arrhythmias reduce cardiac output and commonly occur in the presence of preexisting heart disease. Contents preface, v aknowledgments, viii part 1 basic principles chapter 1 mechanisms of cardiac tachyarrhythmias, 3 chapter 2 introduction to antiarrhythmic drugs, 36 part 2 clinical features of antiarrhythmic drugs chapter 3 class i antiarrhythmic drugs, 55 chapter 4 class ii antiarrhythmic drugs. Antiarrhythmic drugs 1 free download as powerpoint presentation. Clicking on the drug class will link you to the page describing the pharmacology of that drug class and specific drugs. Antiarrhythmic agents antiarrhythmic drugs are used to prevent or treat. The davis basic science cardiovascular laboratory focuses on various aspects of cardiac regeneration and preservation using molecularbased and biomaterialsbased. Class i antiarrhythmic drugs block the voltage gated sodium channel delaying phase. Antiarrhythmic pharmacology by carlos alvarez on prezi. A powerpoint presentation on basics of arrhythmic disorders and their drug therapy suitable for study by undergraduate mbbs students of. Classification and pharmacology of antiarrhythmic drugs.
Ppt antiarrhythmic drugs powerpoint presentation free. Antiarrhythmic drugs nursing pharmacology study guide. Powerpoint lectures on pharmacology of antiarrythmic drugs. Antiarrhythmic drugs are used to prevent recurrent arrhythmias and restore sinus rhythm in patients with cardiac arrhythmias. Basic concepts in pharmacology 4th edition pdf free download. To understand the action and classification of the antiarrhythmic drugs. These pharmacology powerpoint lectures illustrate some of the most relevant aspects of the pharmacology of antiarrhythmic agents.
Antiarrhythmic drug therapy for rhythm control in atrial fibrillation jonathan w. This describes the various antiarrythmic medications in terms of their mechanism of action with regard to the cardiac action. Modernized classification of cardiac antiarrhythmic drugs. Ivmscv pharmacology management of congestive heart failure by marc imhotep 3731 views ivmscv pathophysiology pharmacology and treatment of shock by marc imhotep. Pdf teaching the pharmacology of antiarrhythmic drugs.
Antiarrhythmics are drugs that are used to treat abnormal rhythms of the heart, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and. The long and growing list of nonantiarrhythmic drugs associated with prolongation of the qt interval of the electrocardiogram has generated concern not only for regulatory interventions leading. Antiarrhythmic drugs class 1 and class 3 usmle step 1. Conductivity is the basis of cardiac contraction and relaxation, allowing the heart to beat. Ppt antiarrhythmic drugs powerpoint presentation free to download id. Alright, now in this part of the article, you will be able to access the free pdf download of basic concepts in pharmacology 4th edition pdf using our direct links mentioned at the end of this article. Brief overview of antiarrhythmic drugs for bds and mbbs students. Jun 08, 2019 to better understand this condition, there are two concepts vital to be mastered. Antiarrhythmic drugs exert their effects by decreasing the automaticity of ectopic pacemakers more than that of the sa node. Antiarrhythmic agents prevent reentry by slowing conduction andor increasing the refractory period, thereby converting a unidirectional block into a bidirectional block.
Accumulated studies on the mechanism of antiarrhythmic agents, however, have provided much basic understanding of drug action, especially on the electrophysiological properties of cardiac excitation. These insights provided the scientific basis for a landmark classification of antiarrhythmic drugs based on. Antiarrhythmic drugs antiarrhythmic drugs prevent or treat irregularities of cardiac rhythm half of all cardiac deaths are due to cardiac arrhythmias arrhythmias are due to a disturbance of the electrical impulses which regulate the heart. These agents have a very powerful impact on the cardiac action potential and as a result have the potential for proarrhythmic effects. Dec 18, 2017 there are 5 classes of antiarrhythmic drugs. The section of cardiopulmonary medicine, departments of medicine, physiology, and pharmacology, university of california at davis, school of medicine, davis, calif. Antiarrhythmic drugs knowledge for medical students and. The clinical pharmacology and therapeutic applications of the. Dec 01, 2014 although cardiac sodium channel blocking drugs can exert antiarrhythmic actions, they can also provoke lifethreatening arrhythmias through a variety of mechanisms. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Arrhythmias are the most important cause of sudden cardiac death. Compounds used to prevent or treat cardiac arrhythmias. Atrial fibrillation af, characterised by rapid and irregular activation of the atrium, is the most common arrhythmia in clinical practice, and 2. Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a group of pharmaceuticals that are used to suppress abnormal rhythms of the heart cardiac arrhythmias, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
The clinical pharmacology and therapeutic applications of the antiarrhythmic drugs dean t. Dec 10, 2016 this topic is given in first aid 2015 on page no. The key to the proper use of antiarrhythmic drugs is a thorough knowledge of their mode of action and pharmacology. These insights provided the scientific basis for a landmark classification of antiarrhythmic drugs based on the actions of these drugs on cardiac action poten. Although cardiac sodium channel blocking drugs can exert antiarrhythmic actions, they can also provoke lifethreatening arrhythmias through a variety of mechanisms. Antiarrhythmic drug therapy for rhythm control in atrial. Please note that many of the drugs comprising the first five listed classes have considerable overlap in their pharmacologic properties.
Mechanisms of action of antiarrhythmic drugs springerlink. Ivmscv pharmacology antiarrhythmics authorstream presentation. Pharmacology and physiology for anesthesia sciencedirect. Waks, md and peter zimetbaum, md journal of cardiovascular pharmacology and therapeutics 2016 22. Identify common antiarrhythmic, rate controlling and risk reduction drugs and their initial doses and special considerations be familiar with related necessary diagnostic monitoring labs, ekg identify the goals of drug therapy, rate vs.
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